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Fetal lateral cleft lips are rare congenital deformities characterized by macrostomia with lateral facial muscular diastasis and usually associated with other anomalies, especially periauricular skin tags, bony abnormalities of the maxilla and zygoma, temporalis and ear deformities. We report a case of ‐bilateral lateral facial cleft with single nostril and multiple anomalies observed through prenatal two dimensional and three dimensional ultrasonography examinations.